pentobarbital will decrease the extent or result of trazodone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.pentobarbital will reduce the level or influence of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is a delicate CYP3A4 substrate. Coadministration wi